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Trends Cancer. 2017 Nov;3(11):797-808. doi: 10.1016/j.trecan.2017.09.006. Epub 2017 Nov 6.

Migrating into the Tumor: a Roadmap for T Cells.

Author information

1
Department of Tumor Immunology, Radboud Institute of Molecular Life Sciences, Geert Grooteplein 26-28, 6525 GA, Nijmegen, The Netherlands; Department of Pathology, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands; Joint first authors.
2
Department of Tumor Immunology, Radboud Institute of Molecular Life Sciences, Geert Grooteplein 26-28, 6525 GA, Nijmegen, The Netherlands; Joint first authors.
3
Department of Tumor Immunology, Radboud Institute of Molecular Life Sciences, Geert Grooteplein 26-28, 6525 GA, Nijmegen, The Netherlands; Department of Pathology, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
4
Department of Tumor Immunology, Radboud Institute of Molecular Life Sciences, Geert Grooteplein 26-28, 6525 GA, Nijmegen, The Netherlands.
5
Department of Tumor Immunology, Radboud Institute of Molecular Life Sciences, Geert Grooteplein 26-28, 6525 GA, Nijmegen, The Netherlands; Department of Medical Oncology, Radboudumc, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands. Electronic address: Jolanda.devries@radboudumc.nl.

Abstract

Tumors can be divided into 'hot' (T cell inflamed) or 'cold' (T cell noninflamed) according to the presence of immune cells. In this review, we discuss variables that influence T cell migration into the tumor microenvironment. Chemokines can attract T cells to the tumor site and tumor intrinsic pathways can influence the composition of local chemokines. Tumor-induced vasculature can hamper T cell migration. Other immune cells and tumor-derived molecules can block T cell proliferation and survival. It is important to better understand these mechanisms in order to target them therapeutically. Enhancing T cell infiltration may increase response rates to immunotherapy and increase survival.

KEYWORDS:

T cells; biomarkers; immune cells; immunotherapy; migration; tumor microenvironment.

PMID:
29120755
DOI:
10.1016/j.trecan.2017.09.006
[Indexed for MEDLINE]

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