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Int J Cancer. 2018 May 1;142(9):1738-1747. doi: 10.1002/ijc.31147. Epub 2017 Nov 27.

Chimeric antigen receptor transduced T cells: Tuning up for the next generation.

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Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.
German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ)/National Center for Tumor Diseases (NCT), Heidelberg, Germany.


Chimeric antigen receptor (CAR) T cell therapy has recently achieved impressive clinical outcome in patients with CD19-positive hematologic malignancies. Extrapolation of CAR T cell treatment to solid tumors, however, has not yet yielded similar results. This might be due to intrinsic causes, e.g. insufficient CAR T cell activation or CAR toxicity as well as extrinsic factors displaying an unfavorable tumor environment for CAR T cells by raising physical and chemical barriers. In this review, we discuss the advantages as well as major obstacles of CAR T cell therapy, particularly in the context of solid tumors, and focus on efforts and novel strategies in CAR T cell development.


CAR T cell design; CAR T cells; chimeric antigen receptor (CAR); clinical CAR trials; hematologic malignancies; immunotherapy; solid tumors

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