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Methods Mol Biol. 2018;1693:151-158. doi: 10.1007/978-1-4939-7395-8_13.

Bacteriophage Treatment of Infected Diabetic Foot Ulcers.

Author information

1
Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Lavrentiev Ave. 8, Novosibirsk, 630090, Russian Federation. morozova@niboch.nsc.ru.
2
Institute of Chemical Biology and Fundamental Medicine SB RAS, Laboratory of Molecular Microbiology, Lavrentiev Ave. 8, Novosibirsk, 630090, Russian Federation.
3
Railway Clinical Hospital, Str. Vladimirovsky Spusk 2A, Novosibirsk, 630003, Russian Federation.

Abstract

Diabetic foot ulcers occur as a common complication of diabetes. Healing of the ulcers is largely delayed by the concomitant infection. Antibiotic treatment of infected ulcers is complicated by formation of microbial biofilms , which are often heterogeneous and resistant to antibiotics. Bacteriophage therapy is considered as an additional approach to the treatment of infected wounds. Here, we describe the basic method of application of bacteriophages for treatment of infected diabetic foot ulcers, including ones that are very large.

KEYWORDS:

Antibiotic resistance; Bacteriophage therapy; Diabetes; Diabetic foot ulcer; Lytic bacteriophage; Polymicrobial infection

PMID:
29119439
DOI:
10.1007/978-1-4939-7395-8_13
[Indexed for MEDLINE]

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