Format

Send to

Choose Destination
J Neurosci. 2017 Nov 8;37(45):10792-10799. doi: 10.1523/JNEUROSCI.1824-17.2017.

Emerging Mechanisms Underlying Dynamics of GABAergic Synapses.

Author information

1
Department of Neurobiology and Behavior, State University of New York, Stony Brook, New York 11794-5230.
2
Institut de Biologie de l'Ecole Normale Supérieure, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Ecole Normale Supérieure, PSL Research University, F-75005 Paris, France.
3
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
4
Fondazione Istituto Italiano di Tecnologia, 16163 Genova GE, Italy.
5
National Institute of Child Health and Human Development, Bethesda, Maryland 20892.
6
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada, and.
7
Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland tyagarajan@pharma.uzh.ch.

Abstract

Inhibitory circuits are diverse, yet with a poorly understood cell biology. Functional characterization of distinct inhibitory neuron subtypes has not been sufficient to explain how GABAergic neurotransmission sculpts principal cell activity in a relevant fashion. Our Mini-Symposium brings together several emerging mechanisms that modulate GABAergic neurotransmission dynamically from either the presynaptic or the postsynaptic site. The first two talks discuss novel developmental and neuronal subtype-specific contributions to the excitatory/inhibitory balance and circuit maturation. The next three talks examine how interactions between cellular pathways, lateral diffusion of proteins between synapses, and chloride transporter function at excitatory and inhibitory synapses and facilitate inhibitory synapse adaptations. Finally, we address functional differences within GABAergic interneurons to highlight the importance of diverse, flexible, and versatile inputs that shape network function. Together, the selection of topics demonstrates how developmental and activity-dependent mechanisms coordinate inhibition in relation to the excitatory inputs and vice versa.

KEYWORDS:

CaMKIIa; KCC2; gephyrn; homeostatic plasticity; interneurons; postsynaptic density

PMID:
29118207
PMCID:
PMC5678011
DOI:
10.1523/JNEUROSCI.1824-17.2017
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center