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Am J Physiol Endocrinol Metab. 2018 Feb 1;314(2):E165-E173. doi: 10.1152/ajpendo.00266.2017. Epub 2017 Nov 7.

Exercise training reduces intrahepatic lipid content in people with and people without nonalcoholic fatty liver.

Author information

1
NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center , Maastricht , The Netherlands.
2
Department of Human Biology and Human Movement Sciences, Maastricht University Medical Center , Maastricht , The Netherlands.
3
Department of Radiology, Maastricht University Medical Center , Maastricht , The Netherlands.
4
Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Düsseldorf , Düsseldorf , Germany.
5
German Center for Diabetes Research, München-Neuherberg, Düsseldorf , Germany.
6
Translational Research Institute for Metabolism and Diabetes, Florida Hospital , Orlando, Florida.
7
Clinical and Molecular Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute , Orlando, Florida.
8
Division of Endocrinology, Department of Internal Medicine, Maastricht University Medical Center , Maastricht , The Netherlands.
9
Medical Faculty, Division of Endocrinology and Diabetology, Heinrich-Heine University Düsseldorf , Düsseldorf , Germany.

Abstract

Exercise training reduces intrahepatic lipid (IHL) content in people with elevated liver fat content. It is unclear, however, whether exercise training reduces IHL content in people with normal liver fat content. Here, we measured the effect of exercise training on IHL content in people with and people without nonalcohol fatty liver. We further measured changes in insulin sensitivity and hepatic energy metabolism. Eleven males with nonalcoholic fatty liver (NAFL) and 11 body mass index-matched individuals without nonalcoholic fatty liver (CON) completed a 12-wk supervised exercise training program. IHL content (proton magnetic resonance spectroscopy), maximal oxidative capacity (V̇o2max, spiroergometry), total muscle strength, body composition, insulin sensitivity (hyperinsulinemic-euglycemic clamp), hepatic ATP-to-total phosphorus ratio, and the hepatic phosphomonoester-to-phosphodiester (PME/PDE) ratio (phosphorus magnetic resonance spectroscopy) were determined. IHL content reduced with exercise training ( P = 0.014) in the whole study population. The relative reduction in IHL content was comparable in NAFL (-34.5 ± 54.0%) and CON (-28.3 ± 60.1%) individuals ( P = 0.800). V̇o2max ( P < 0.001), total muscle strength ( P < 0.001), and skeletal muscle insulin sensitivity ( P = 0.004) increased, whereas adipose tissue ( P = 0.246) and hepatic ( P = 0.086) insulin sensitivity did not increase significantly. Hepatic ATP-to-total phosphorus ratio ( P = 0.987) and PME/PDE ratio ( P = 0.792) did not change. Changes in IHL content correlated with changes in body weight ( r = 0.451, P = 0.035) and changes in hepatic PME/PDE ratio ( r = 0.569, P = 0.019). In conclusion, exercise training reduced intrahepatic lipid content in people with nonalcoholic fatty liver and in people with normal intrahepatic lipid content, and the percent reduction in intrahepatic lipid content was similar in both groups.

KEYWORDS:

hyperinsulinemic-euglycemic clamp; insulin resistance; magnetic resonance spectroscopy

PMID:
29118014
DOI:
10.1152/ajpendo.00266.2017
[Indexed for MEDLINE]
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