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Chron Respir Dis. 2018 May;15(2):138-145. doi: 10.1177/1479972317736293. Epub 2017 Nov 8.

Inflammatory biomarkers and radiologic measurements in never-smokers with COPD: A cross-sectional study from the CODA cohort.

Author information

1
1 Samsung Medical Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, South Korea.
2
2 Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, Chuncheon, South Korea.
3
3 Department of Radiology, Kangwon National University Hospital, Chuncheon, South Korea.
4
4 Statistics and Data Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, South Korea.
5
5 Department of Digital Health, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Seoul, South Korea.

Abstract

Various biomarkers have emerged as potential surrogates to represent various subgroups of chronic obstructive pulmonary disease (COPD), which manifest with different phenotypes. However, the biomarkers representing never-smokers with COPD have not yet been well elucidated. The aim of this study was to evaluate the associations of certain serum and radiological biomarkers with the presence of COPD in never-smokers. To explore the associations of serum and radiological biomarkers with the presence of COPD in never-smokers, we conducted a cross-sectional patient cohort study composed of never-smokers from the COPD in Dusty Areas (CODA) cohort, consisting of subjects living in dusty areas near cement plants in South Korea. Of the 131 never-smokers in the cohort, 77 (58.8%) had COPD. There were no significant differences in the number of subjects with high levels of inflammatory biomarkers (>90th percentile of never-smokers without COPD), including white blood cell count, total bilirubin, interleukin (IL)-6, IL-8, and C-reactive protein, or radiologic measurements (including emphysema index and mean wall area percentage) between never-smokers with COPD and those without COPD. However, the number of subjects with high uric acid was significantly higher in never-smokers with COPD than never-smokers without COPD (31.2% (24/77) vs. 11.1% (6/54); p = 0.013). In addition, multivariate analysis revealed that high uric acid was significantly associated with the presence of COPD in never-smokers (adjusted relative risk: 1.63; 95% confidence interval: 1.21, 2.18; p = 0.001). Our study suggests that high serum levels of uric acid might be a potential biomarker for assessing the presence of COPD in never-smokers.

KEYWORDS:

Serum and radiologic biomarker; chronic obstructive pulmonary disease; never-smoker; uric acid

PMID:
29117798
PMCID:
PMC5958470
DOI:
10.1177/1479972317736293
[Indexed for MEDLINE]
Free PMC Article

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