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Int J Psychophysiol. 2018 Sep;131:131-138. doi: 10.1016/j.ijpsycho.2017.11.002. Epub 2017 Nov 5.

Heart rate variability mediates the link between rumination and depressive symptoms: A longitudinal study.

Author information

1
Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; Stress Physiology Lab, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Italy.
2
Department of Psychology, The Ohio State University, Columbus, OH, USA.
3
Institute of Psychology, Leiden University, Leiden, The Netherlands.
4
Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; Department of Psychology, Sapienza University of Rome, Italy. Electronic address: cristina.ottaviani@uniroma1.it.

Abstract

Ruminative thinking about negative feelings has been prospectively associated with increases in depressive symptoms and heightened risk for new onsets of major depression. One putative pathophysiological mechanism underlying this link might be represented by autonomic nervous system dysfunction. The objective of this longitudinal study was to evaluate the interplay between rumination, autonomic function (as revealed by heart rate variability (HRV) analysis), and depressive symptoms in healthy young subjects, over a three-year period. Rumination and depressive symptoms were evaluated in twenty-two women and twenty men at three assessment points (Time 0, 1 and 2) by the score on the Ruminative Response Scale, and the Center for Epidemiological Studies Depression Scale, respectively. Vagally-mediated HRV was assessed in a laboratory session (Time 0) and in two ambulatory sessions at Time 1 and Time 2 (~13 and 34months after Time 0, respectively). Ruminative thinking was found to be (i) a stable trait characteristic, (ii) more prevalent in women than men, and (iii) positively correlated with depressive symptoms. Moreover, resting HRV was negatively correlated with both rumination and depressive symptoms. Finally, HRV at Time 1 mediated the relationship between rumination at Time 0 and depressive symptoms at Time 2. We conclude that autonomic dysfunction, specifically low vagal tone, may be prospectively implicated in the generation of depressive symptoms in a non-clinical setting.

KEYWORDS:

Depressive symptoms; Heart rate variability; Longitudinal; Mediation; Rumination

PMID:
29117509
DOI:
10.1016/j.ijpsycho.2017.11.002
[Indexed for MEDLINE]

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