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Pediatr Crit Care Med. 2018 Feb;19(2):89-97. doi: 10.1097/PCC.0000000000001367.

Cognitive Development One Year After Infantile Critical Pertussis.

Author information

1
Department of Pediatrics, Children's National Medical Center, Washington, DC.
2
Department of Psychiatry, University of North Carolina at Chapel Hill, Asheville, NC.
3
Department of Pediatrics, Univesity of Utah, Salt Lake City, UT.
4
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
5
Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA.
6
Department of Child Health, Phoenix Children's Hospital, Phoenix, AZ.
7
Department of Pediatrics, Mattel Children's Hospital UCLA, Los Angeles, CA.
8
Department of Pediatrics, Children's Hospital of Michigan, Detroit, MI.
9
Department of Anesthesiology and Critical Care Medicine, Children's Hospital Los Angeles, Los Angeles, CA.
10
Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, Ann Arbor, MI.
11
Department of Pediatrics, Le Bonheur Children's Hospital, Memphis. TN.
12
Department of Pediatrics, Seattle Children's Hospital, Seattle, WA.
13
Department of Pediatrics, Arkansas Children's Hospital, Little Rock, AR.
14
Department of Pediatrics, Virginia Commonwealth University, Richmond, VA.
15
Departments of Pediatrics and Biochemistry, St. Louis Children's Hospital, St. Louis, MO.
16
Pediatric Trauma and Critical Illness Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.

Abstract

OBJECTIVES:

Pertussis can cause life-threatening illness in infants. Data regarding neurodevelopment after pertussis remain scant. The aim of this study was to assess cognitive development of infants with critical pertussis 1 year after PICU discharge.

DESIGN:

Prospective cohort study.

SETTING:

Eight hospitals comprising the Eunice Kennedy Shriver National Institute for Child Health and Human Development Collaborative Pediatric Critical Care Research Network and 18 additional sites across the United States.

PATIENTS:

Eligible patients had laboratory confirmation of pertussis infection, were less than 1 year old, and were admitted to the PICU for at least 24 hours.

INTERVENTIONS:

The Mullen Scales of Early Learning was administered at a 1-year follow-up visit. Functional status was determined by examination and parental interview.

MEASUREMENTS AND MAIN RESULTS:

Of 196 eligible patients, 111 (57%) completed the Mullen Scales of Early Learning. The mean scores for visual reception, receptive language, and expressive language domains were significantly lower than the norms (p < 0.001), but not fine and gross motor domains. Forty-one patients (37%) had abnormal scores in at least one domain and 10 (9%) had an Early Learning Composite score 2 or more SDs below the population norms. Older age (p < 0.003) and Hispanic ethnicity (p < 0.008) were associated with lower mean Early Learning Composite score, but presenting symptoms and PICU course were not.

CONCLUSIONS:

Infants who survive critical pertussis often have neurodevelopmental deficits. These infants may benefit from routine neurodevelopmental screening.

PMID:
29117060
PMCID:
PMC5796844
DOI:
10.1097/PCC.0000000000001367
[Indexed for MEDLINE]
Free PMC Article

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