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Nat Commun. 2017 Nov 7;8(1):1357. doi: 10.1038/s41467-017-01185-0.

Odor-evoked inhibition of olfactory sensory neurons drives olfactory perception in Drosophila.

Cao LH1,2,3,4, Yang D1,2,3, Wu W1,2,3, Zeng X5, Jing BY1,2,3, Li MT1,2,3,6, Qin S4, Tang C3,4, Tu Y4,7, Luo DG8,9,10,11.

Author information

1
State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing, 100871, China.
2
IDG-McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.
3
Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
4
Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China.
5
United States Army Medical Research Institute of Infectious Diseases, Frederick, MD, 21702, USA.
6
Peking University-Tsinghua University-National Institute of Biological Sciences Joint Graduate Program (PTN), Peking University, Beijing, 100871, China.
7
IBM T.J. Watson Research Center, Yorktown Heights, NY, 10598, USA.
8
State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University, Beijing, 100871, China. dgluo@pku.edu.cn.
9
IDG-McGovern Institute for Brain Research, Peking University, Beijing, 100871, China. dgluo@pku.edu.cn.
10
Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China. dgluo@pku.edu.cn.
11
Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China. dgluo@pku.edu.cn.

Abstract

Inhibitory response occurs throughout the nervous system, including the peripheral olfactory system. While odor-evoked excitation in peripheral olfactory cells is known to encode odor information, the molecular mechanism and functional roles of odor-evoked inhibition remain largely unknown. Here, we examined Drosophila olfactory sensory neurons and found that inhibitory odors triggered outward receptor currents by reducing the constitutive activities of odorant receptors, inhibiting the basal spike firing in olfactory sensory neurons. Remarkably, this odor-evoked inhibition of olfactory sensory neurons elicited by itself a full range of olfactory behaviors from attraction to avoidance, as did odor-evoked olfactory sensory neuron excitation. These results indicated that peripheral inhibition is comparable to excitation in encoding sensory signals rather than merely regulating excitation. Furthermore, we demonstrated that a bidirectional code with both odor-evoked inhibition and excitation in single olfactory sensory neurons increases the odor-coding capacity, providing a means of efficient sensory encoding.

PMID:
29116083
PMCID:
PMC5676773
DOI:
10.1038/s41467-017-01185-0
[Indexed for MEDLINE]
Free PMC Article

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