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Int J Cancer. 2018 Mar 15;142(6):1189-1201. doi: 10.1002/ijc.31146. Epub 2017 Nov 22.

Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.

Author information

1
National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
2
Division of Human Nutrition, Wageningen University & Research, Wageningen, The Netherlands.
3
International Agency for Research on Cancer (IARC-WHO), Lyon, France.
4
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway.
5
Department of Gastroenterology and Hepatology, University Medical Center Utrecht, The Netherlands.
6
Department of Gastroenterology and Hepatology, Radboud University Medical Center, Nijmegen, The Netherlands.
7
Department of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, Atlanta, GA.
8
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
9
Department of Clinical Chemistry, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
10
Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
11
Cancer Registry of Norway, Institute for Population-based Cancer Research, Oslo, Norway.
12
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
13
Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.
14
Danish Cancer Society Research Center, Copenhagen, Denmark.
15
Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus C, Denmark.
16
Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France.
17
Gustave Roussy, Villejuif, F-94805, France.
18
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
19
Department of Epidemiology, German Institute for Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany.
20
Hellenic Health Foundation, Athens, Greece.
21
WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Greece.
22
Department of Critical Care Medicine and Pulmonary Services, University of Athens Medical School, Evangelismos Hospital, Athens, Greece.
23
Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.
24
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
25
Cancer Registry and Histopathology Unit, "Civic - M.P.Arezzo" Hospital, ASP Ragusa, (Italy).
26
Dipartimento di medicina clinica e chirurgia, Federico II university, Naples, Italy.
27
Department of Medical Sciences, University of Torino, Torino, Italy.
28
Italian Institute for Genomic Medicine (IIGM/HuGeF), Torino, Italy.
29
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
30
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom.
31
Oviedo University, Asturias, Spain.
32
Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.
33
CIBER de Epidemiología y Salud Pública (CIBERESP), Spain.
34
Public Health Direction and Biodonostia-Ciberesp, Basque Regional Health Department, San Sebastian, Spain.
35
Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
36
Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain.
37
Navarra Public Health Institute, Pamplona, Spain.
38
Navarra Institute for Health Research (IdiSNA) Pamplona, Spain.
39
Department of Surgery, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.
40
Department of Surgery, Endocrine-Sarcoma unit, Skane University Hospital, Lund, Sweden.
41
Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
42
Department of Biobank Research, Umeå University, Umeå, Sweden.
43
The Medical Biobank at Umeå University, Umeå, Sweden.
44
MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.
45
University of Cambridge, Cambridge, United Kingdom.
46
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.
47
Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Abstract

Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.

KEYWORDS:

cancer epidemiology; nested case-control study; pancreatic cancer; vitamin D

PMID:
29114875
PMCID:
PMC5813219
DOI:
10.1002/ijc.31146
[Indexed for MEDLINE]
Free PMC Article

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