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Ocul Surf. 2018 Jan;16(1):58-69. doi: 10.1016/j.jtos.2017.11.002. Epub 2017 Nov 4.

The diagnosis of limbal stem cell deficiency.

Author information

1
Stein Eye Institute, Cornea Division, David Geffen School of Medicine, University of California, Los Angeles, USA; Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
2
Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
3
Stein Eye Institute, Cornea Division, David Geffen School of Medicine, University of California, Los Angeles, USA. Electronic address: deng@jsei.ucla.edu.

Abstract

Limbal stem cells (LSCs) maintain the normal homeostasis and wound healing of corneal epithelium. Limbal stem cell deficiency (LSCD) is a pathologic condition that results from the dysfunction and/or an insufficient quantity of LSCs. The diagnosis of LSCD has been made mainly based on medical history and clinical signs, which often are not specific to LSCD. Methods to stage the severity of LSCD have been lacking. With the application of newly developed ocular imaging modalities and molecular methods as diagnostic tools, standardized quantitative criteria for the staging of LSCD can be established. Because of these recent advancements, effective patient-specific therapy for different stages of LSCD may be feasible.

KEYWORDS:

Anterior-segment optical coherence tomography; Conjunctival marker; Diagnosis; Impression cytology; In vivo confocal microscopy; Limbal stem cell deficiency; Molecular marker

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