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Antioxid Redox Signal. 2018 Dec 1;29(16):1660-1690. doi: 10.1089/ars.2017.7423. Epub 2017 Dec 20.

Modulators of Redox Metabolism in Head and Neck Cancer.

Author information

1
1 Department of Internal Medicine, Section on Molecular Medicine, Wake Forest School of Medicine , Winston-Salem, North Carolina.
2
2 Departments of Pharmacology, Radiation Oncology, and Simmons Comprehensive Cancer Center, UT Southwestern Medical Center , Dallas, Texas.
3
3 Cleveland Clinic Foundation , Cleveland, Ohio.
4
4 Department of Internal Medicine, Division of Hematology-Oncology, UT Southwestern Medical Center , Dallas, Texas.
5
5 Department of Internal Medicine, Section of Hematology and Oncology, Wake Forest School of Medicine , Winston-Salem, North Carolina.
6
6 The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University , Atlanta, Georgia .

Abstract

SIGNIFICANCE:

Head and neck squamous cell cancer (HNSCC) is a complex disease characterized by high genetic and metabolic heterogeneity. Radiation therapy (RT) alone or combined with systemic chemotherapy is widely used for treatment of HNSCC as definitive treatment or as adjuvant treatment after surgery. Antibodies against epidermal growth factor receptor are used in definitive or palliative treatment. Recent Advances: Emerging targeted therapies against other proteins of interest as well as programmed cell death protein 1 and programmed death-ligand 1 immunotherapies are being explored in clinical trials.

CRITICAL ISSUES:

The disease heterogeneity, invasiveness, and resistance to standard of care RT or chemoradiation therapy continue to constitute significant roadblocks for treatment and patients' quality of life (QOL) despite improvements in treatment modality and the emergence of new therapies over the past two decades.

FUTURE DIRECTIONS:

As reviewed here, alterations in redox metabolism occur at all stages of HNSCC management, providing opportunities for improved prevention, early detection, response to therapies, and QOL. Bioinformatics and computational systems biology approaches are key to integrate redox effects with multiomics data from cells and clinical specimens and to identify redox modifiers or modifiable target proteins to achieve improved clinical outcomes. Antioxid. Redox Signal.

KEYWORDS:

HNSCC; head and neck; oxidative stress; redox; squamous cancer

PMID:
29113454
PMCID:
PMC6207163
[Available on 2019-12-01]
DOI:
10.1089/ars.2017.7423

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