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Zhonghua Gan Zang Bing Za Zhi. 2017 Sep 20;25(9):651-654. doi: 10.3760/cma.j.issn.1007-3418.2017.09.003.

[Clinical application of mesenchymal stem cells in treatment of acute-on-chronic liver failure and related research advances].

[Article in Chinese; Abstract available in Chinese from the publisher]

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Department of Infectious Diseases, The Second Hostipal, Affiliated to Chongqing Medical University, Chongqing 400010, China.


in English, Chinese

Acute-on-chronic liver failure is a syndrome characterized by acute exacerbation of chronic hepatitis, organ failure, and high mortality. Clinical treatment of acute-on-chronic liver failure included comprehensive medical treatment, artificial liver support system, and liver transplantation, but such methods have their own shortcomings and patients tend to have a poor prognosis. Mesenchymal stem cells (MSCs), as a new type of cell therapy, have wide sources and are easy to extract and culture. Many studies have shown that MSC treatment not only helps to achieve a high survival rate, but also has good tolerability and safety; therefore, the clinical value of MSCs has become a hot research topic. This article reviews the clinical studies on acute-on-chronic liver failure, related mechanisms, and research advances, in order to provide a reference for future clinical trials and application.


Acute-on-chronic liver failure; Cell transplantation; Mesenchymal stem cells

[Indexed for MEDLINE]

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