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Oncotarget. 2017 Jul 5;8(46):81377-81386. doi: 10.18632/oncotarget.18996. eCollection 2017 Oct 6.

Altered putamen functional connectivity is associated with anxiety disorder in Parkinson's disease.

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Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Contributed equally


In this study, we used resting state-functional magnetic resonance imaging (rs-fMRI) to explore altered putamen functional connectivity (FC) in Parkinson's disease patients with anxiety disorder. We divided 65 Parkinson's disease patients into anxiety (PD-A; n=18) and non-anxiety (PD-NA; n=45) groups based on a Hamilton Anxiety Rating Scale cutoff score of 12. The PD-A patients exhibited altered putamen FC with cortical and subcortical regions. The PD-A patients showed enhanced putamen FC with the caudatum, which correlated with increased emotional processing during anxiety. Decreased putamen FC with the orbitofrontal gyrus and cerebellum also correlated with increased anxiety in Parkinson's disease. Our findings demonstrate that anxiety disorder in Parkinson's disease is associated with abnormal putamen FC networks, especially with caudatum, orbitofrontal gyrus and cerebellum.


FC; Parkinson’s disease; anxiety; pathogenesis; resting state functional magnetic resonance imaging

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no potential conflicts of interest.

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