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Oncol Lett. 2017 Nov;14(5):5890-5898. doi: 10.3892/ol.2017.6959. Epub 2017 Sep 15.

CD44+/CD24- phenotype predicts a poor prognosis in triple-negative breast cancer.

Author information

1
Department of Medical Oncology, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
2
Department of Medical Oncology, The Fourth People's Hospital of Zibo, Zibo, Shandong 255000, P.R. China.
3
Department of Pathology, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
4
Department of Radiation Oncology, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.

Abstract

Cancer stem cells are enriched in triple-negative breast cancer (TNBC) tumor tissues, which present strong capacities of proliferation and tumorigenicity. The present study detected the distribution of cancer stem cell markers cluster of differentiation (CD)44/CD24 and analyzed the clinical outcomes of different CD44/CD24 phenotypes in patients with TNBC. Multivariate Cox regression analyses were performed with regard to the prognostic value of cancer stem cell markers CD44/CD24, aldehyde dehydrogenase 1 and other baseline clinical characteristics, including tumor size, lymph node involved, adjuvant chemotherapy, Ki-67, breast cancer susceptibility gene 1, cellular tumor antigen p53, vimentin and basal-like status. The multivariate analyses showed that three of these factors, CD44/CD24 phenotype, basal-like status and number of lymph nodes involved, had an impact on overall survival. Furthermore, patients with CD44+/CD24- phenotype, basal-like tumors and ≥4 lymph nodes involved had a significantly worse prognosis. The expression of CD44 and CD24 was detected by double-staining immunohistochemistry, which can locate cancer stem cells individually. Overall, the present results indicated that CD44/CD24 status evaluated by double-staining immunohistochemistry constitutes an independent prognostic factor for TNBC.

KEYWORDS:

CD24; CD44; cancer stem cells; prognosis; triple-negative breast cancer

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