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Dev Cell. 2017 Nov 6;43(3):257-258. doi: 10.1016/j.devcel.2017.10.009.

Evidence for Converging DNA Methylation Pathways in Placenta and Cancer.

Author information

1
Department of Medical Genetics, University of British Columbia, Vancouver, Canada. Electronic address: mlorincz@mail.ubc.ca.
2
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; University of Basel, Faculty of Sciences, Petersplatz 1, 4001 Basel, Switzerland. Electronic address: dirk@fmi.ch.

Abstract

CpG island promoters are generally devoid of DNA methylation in somatic cells but are frequently methylated during tumorigenesis. Reporting recently in Nature, Smith et al. (2017) show that the signaling-induced methylome in early extraembryonic tissues resembles that of many cancers, suggesting that placental nuclear programming might be co-opted in tumorigenesis.

PMID:
29112847
DOI:
10.1016/j.devcel.2017.10.009
[Indexed for MEDLINE]
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