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Nucleic Acids Res. 2018 Jan 4;46(D1):D435-D439. doi: 10.1093/nar/gkx1069.

Gene3D: Extensive prediction of globular domains in proteins.

Author information

1
Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK.
2
School of Biosciences and Biotechnology, Faculty of Science and Technology, University Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
3
Bristol Life Sciences Building, University of Bristol, Bristol Life Sciences Building, Bristol, BS8 1TQ, UK.
4
Oxford Brookes University, Faculty of Health and Life Sciences, Oxford, Oxfordshire, UK.

Abstract

Gene3D (http://gene3d.biochem.ucl.ac.uk) is a database of globular domain annotations for millions of available protein sequences. Gene3D has previously featured in the Database issue of NAR and here we report a significant update to the Gene3D database. The current release, Gene3D v16, has significantly expanded its domain coverage over the previous version and now contains over 95 million domain assignments. We also report a new method for dealing with complex domain architectures that exist in Gene3D, arising from discontinuous domains. Amongst other updates, we have added visualization tools for exploring domain annotations in the context of other sequence features and in gene families. We also provide web-pages to visualize other domain families that co-occur with a given query domain family.

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