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Chem Rev. 2018 Feb 14;118(3):1253-1337. doi: 10.1021/acs.chemrev.7b00205. Epub 2017 Nov 7.

Chemical Biology of H2S Signaling through Persulfidation.

Author information

1
Univeristy of Bordeaux, IBGC, UMR 5095 , F-33077 Bordeaux, France.
2
CNRS, IBGC, UMR 5095 , F-33077 Bordeaux, France.
3
Laboratorio de EnzimologĂ­a, Facultad de Ciencias and Center for Free Radical and Biomedical Research, Universidad de la Republica , 11400 Montevideo, Uruguay.
4
Department of Biological Chemistry, University of Michigan Medical School , Ann Arbor, Michigan 48109-0600, United States.

Abstract

Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for understanding the physiological and pharmacological effects of H2S. Due to the inherent instability of persulfides, their chemistry is understudied. In this review, we discuss the biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation. We cover the chemical biology of persulfides and the chemical probes for detecting them. We conclude by discussing the roles ascribed to protein persulfidation in cell signaling pathways.

PMID:
29112440
PMCID:
PMC6029264
[Available on 2019-02-14]
DOI:
10.1021/acs.chemrev.7b00205

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