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Tremor Other Hyperkinet Mov (N Y). 2017 Oct 9;7:499. doi: 10.7916/D8Z89QW7. eCollection 2017.

Abnormalities of Eye-Hand Coordination in Patients with Writer's Cramp: Possible Role of the Cerebellum.

Author information

1
Department of Clinical Neurosciences, National Institute of Mental Health & Neurosciences, Bangalore, Karnataka, India.
2
Department of Neurology, National Institute of Mental Health & Neurosciences, Bangalore, Karnataka, India.
3
Department of Biostatistics, National Institute of Mental Health & Neurosciences, Bangalore, Karnataka, India.
4
Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health & Neurosciences, Bangalore, Karnataka, India.

Abstract

Background:

Writer's cramp (WC) is one of the commonly observed focal dystonias. The pathophysiology of WC has not been fully understood. The role of the cerebellum has been increasingly recognized in the pathogenesis of dystonia. As the cerebellum is crucial for maintaining accurate eye-hand coordination (EHC), its role in the pathogenesis of WC can be investigated by studying the EHC in patients with WC.

Methods:

Fifteen patients with WC (women:men, 3:12) and 15 age- and gender-matched controls performed oculomotor and EHC tasks. A visually guided stimulus (VGS) task was first performed with eye-only condition (EOC) and then with EHC.

Results:

A significant interaction between the groups (controls and patients) and tasks (EOC and EHC) with age as a covariate confirmed that the two groups reacted differently to the tasks in saccadic latency (F(1,27) = 4.8; p = 0.039) and average saccade acceleration (F(1,27) = 10.6; p = 0.003). The curvature index of acceleration of the hand was significantly more in patients compared to controls (patients vs. controls, 2.4±0.4 vs. 1.8±0.2, p = 0.01). While performing the EHC task, there was a significant correlation of the Writer's Cramp Rating Score with the average saccadic speed (-0.61, p = 0.016), peak saccadic deceleration (0.59, p = 0.019) and average saccadic acceleration (-0.63, p = 0.012).

Discussion:

Saccadic acceleration and latency are abnormal while performing EHC tasks in patients with WC. Our study gives further insights into the possible role of the cerebellum in the pathogenesis of WC.

KEYWORDS:

Writer’s cramp; cerebellum; eye–hand coordination; focal dystonia

PMID:
29109905
PMCID:
PMC5666016
DOI:
10.7916/D8Z89QW7
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

Funding: This study was funded by a grant from the Department of Biotechnology, India (No. BT/PR4986/MED/30/753/2012). Conflicts of interest: The authors report no conflict of interest. Ethics Statement: This study was performed in accordance with the ethical standards detailed in the Declaration of Helsinki. The authors’ institutional ethics committee has approved this study and all patients have provided written informed consent.

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