Send to

Choose Destination
Magn Reson Imaging. 2018 Feb;46:75-80. doi: 10.1016/j.mri.2017.10.009. Epub 2017 Nov 3.

Quantitative assessment of liver function with whole-liver T1rho mapping at 3.0T.

Author information

Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China.
Shandong Medical Imaging Research Institute, Shandong University, Jinan, Shandong, China.
Department of Radiology, Shanghai Institute of Medical Imaging, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Philips Healthcare, Hong Kong, China.
Molecular Imaging and Neuropathology Division, Department of Psychiatry, Columbia University & New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA. Electronic address:



To assess the segmental liver function in healthy subjects and liver cirrhosis (LC) patients with different Child-Pugh grades using whole-liver T1rho mapping at 3.0T.


Thirty-three healthy volunteers and 33 patients with clinically diagnosed LC were examined using a three-dimensional (3D) whole-liver coverage T1rho mapping. T1rho maps were calculated from five respiratory-triggered sequences with different spin-lock durations (0, 10, 20, 40, and 60ms). The patients were classified into group A with Child-Pugh A cirrhosis and group B with Child-Pugh B or C cirrhosis. The hepatic T1rho values in different segments of the healthy volunteers and LC patients were compared, and receiver operating characteristic curves (ROC) were plotted to determine the performance of T1rho.


The median T1rho value of the patients (Child-Pugh class A: 47.07ms; Child-Pugh classes B and C: 51.09ms) was significantly higher than that of the healthy volunteers (39.37ms, P<0.001). No remarkable variations among different hepatic segments in LC patients with various Child-Pugh grades were found (P>0.05). The T1rho values of the liver parenchyma were significantly correlated with albumin (r=-0.590, P<0.001) and prothrombin time (r=0.601, P<0.001). The T1rho values in patients increased with an increase in the Child-Pugh classification (r=0.574, P<0.001).


The whole-liver coverage T1rho sequence at 3.0T was feasible for the assessment of segmental liver function. T1rho relaxation might be a potential biomarker for the estimation of liver function in LC patients.


Liver cirrhosis; Liver function; Magnetic resonance imaging; Quantification; T1rho relaxation

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center