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Oncotarget. 2017 May 23;8(45):79337-79346. doi: 10.18632/oncotarget.18107. eCollection 2017 Oct 3.

Tumor necrosis and complete resection has significant impacts on survival in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma.

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Department of Hemato-Oncology, Hanyang University Hanmaeum Changwon Hospital, Changwon, Korea.
Department of Hematology-Oncology, Pusan National University Hospital, Busan, Korea.
Department of Hematology, Chonbuk National University Hospital, Jeonju, Korea.
Department of Hematology, Busan Haeundae Paik Hospital, Busan, Korea.
Department of Nuclear Medicine, Pusan National University Hospital, Busan, Korea.
Department of Nuclear Medicine, Chonbuk National University Hospital, Jeonju, Korea.
Department of Nuclear Medicine, Busan Haeundae Paik Hospital, Busan, Korea.
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.


Tumor necrosis (TN) is associated with worse prognosis in several solid cancers. Whether TN predicts poor outcome in natural killer cell / T cell lymphoma (NKTCL) is unclear. We investigated the clinical impact of TN on survival and other novel prognostic parameters in upper aero-digestive tract (UAT) NKTCL of 100 patients with limited stage. TN was significantly associated with poor performance status (p = 0.049), high Korean Prognostic Index score (p = 0.024), high C-reactive protein/albumin ratio (p = 0.003), higher maximum standard uptake value on positron emission tomography/computed tomography (PET/CT) (p = 0.008) and higher metabolic tumor volume (MTV) on PET/CT (p < 0.001). In univariate and multivariate analyses, progression-free survival and overall survival were independently associated with High MTV status (p = 0.001, p = 0.032), TN (p = 0.018, p = 0.009), local tumor invasiveness (p = 0.007, p = 0.035), complete resection (p = 0.020, p = 0.028) and regional lymph node involvement (p < 0.001, p < 0.001). TN and complete resection are concluded to be novel independent prognostic factors in patients with UAT NKTCL.


complete resection; extranodal natural killer/T-cell lymphoma; prognosis; tumor necrosis

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest.

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