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Oncotarget. 2017 May 23;8(45):79337-79346. doi: 10.18632/oncotarget.18107. eCollection 2017 Oct 3.

Tumor necrosis and complete resection has significant impacts on survival in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma.

Author information

1
Department of Hemato-Oncology, Hanyang University Hanmaeum Changwon Hospital, Changwon, Korea.
2
Department of Hematology-Oncology, Pusan National University Hospital, Busan, Korea.
3
Department of Hematology, Chonbuk National University Hospital, Jeonju, Korea.
4
Department of Hematology, Busan Haeundae Paik Hospital, Busan, Korea.
5
Department of Nuclear Medicine, Pusan National University Hospital, Busan, Korea.
6
Department of Nuclear Medicine, Chonbuk National University Hospital, Jeonju, Korea.
7
Department of Nuclear Medicine, Busan Haeundae Paik Hospital, Busan, Korea.
8
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.

Abstract

Tumor necrosis (TN) is associated with worse prognosis in several solid cancers. Whether TN predicts poor outcome in natural killer cell / T cell lymphoma (NKTCL) is unclear. We investigated the clinical impact of TN on survival and other novel prognostic parameters in upper aero-digestive tract (UAT) NKTCL of 100 patients with limited stage. TN was significantly associated with poor performance status (p = 0.049), high Korean Prognostic Index score (p = 0.024), high C-reactive protein/albumin ratio (p = 0.003), higher maximum standard uptake value on positron emission tomography/computed tomography (PET/CT) (p = 0.008) and higher metabolic tumor volume (MTV) on PET/CT (p < 0.001). In univariate and multivariate analyses, progression-free survival and overall survival were independently associated with High MTV status (p = 0.001, p = 0.032), TN (p = 0.018, p = 0.009), local tumor invasiveness (p = 0.007, p = 0.035), complete resection (p = 0.020, p = 0.028) and regional lymph node involvement (p < 0.001, p < 0.001). TN and complete resection are concluded to be novel independent prognostic factors in patients with UAT NKTCL.

KEYWORDS:

complete resection; extranodal natural killer/T-cell lymphoma; prognosis; tumor necrosis

Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest.

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