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PLoS One. 2017 Nov 6;12(11):e0187683. doi: 10.1371/journal.pone.0187683. eCollection 2017.

Local application of an ibandronate/collagen sponge improves femoral fracture healing in ovariectomized rats.

Guo J1,2,3, Zhang Q1,2,3, Li J1,2,3, Liu Y4, Hou Z1,2, Chen W1,2,3, Jin L1,2,3, Tian Y1,2,3, Ju L1,2,3, Liu B1,2,3, Dong T1,2,3, Zhang F1,2,3, Zhang Y1,2,3.

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Department of Orthopaedic Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang, P. R., China.
Key Laboratory of Orthopaedic Biomechanics of Hebei Province, Shijiazhuang, P. R., China.
Orthopaedic Research Institution of Hebei Province, Hebei, P. R., China.
VSD Medical Science & Technology Co., Ltd, Hubei, P. R., China.


Non-union is a major clinical problem in the healing of fractures, especially in patients with osteoporosis. The systemic administration of drugs is time consuming and large doses are demanding and act slowly, whereas local release acts rapidly, increases the quality and quantity of the bone tissue. We hypothesize that local delivery demonstrates better therapeutic effects on an osteoporotic fracture. The aim of this paper is to investigate the effect of the local application of ibandronate loaded with a collagen sponge on regulating bone formation and remodeling in an osteoporotic rat model of fracture healing. We found that the local delivery of ibandronate exhibited excellent effects on improving the bone microarchitecture and suppressed effects on bone remodeling. At 4 weeks, more callus formation and improvement of mechanical character and microstructure were observed in a local delivery via μCT, mechanical test, histological research and serum analysis. The suppression of bone remodeling was compared with a systemic treatment at 12 weeks, and the structural mechanical properties and microarchitecture were also improved with local delivery. This research identifies an earlier, safer and integrated approach for local delivery of ibandronate with collagen and provides a better strategy for the treatment of osteoporotic fracture in rats.

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