Format

Send to

Choose Destination
Semin Cell Dev Biol. 2018 Jun;78:107-115. doi: 10.1016/j.semcdb.2017.10.007. Epub 2017 Nov 6.

Development and connectivity of the habenular nuclei.

Author information

1
Carnegie Institution for Science, Department of Embryology, 3520 San Martin Drive Baltimore, MD 21218, USA; Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA.
2
Carnegie Institution for Science, Department of Embryology, 3520 San Martin Drive Baltimore, MD 21218, USA; Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: halpern@carnegiescience.edu.

Abstract

Accumulating evidence has reinforced that the habenular region of the vertebrate dorsal forebrain is an essential integrating center, and a region strongly implicated in neurological disorders and addiction. Despite the important and diverse neuromodulatory roles the habenular nuclei play, their development has been understudied. The emphasis of this review is on the dorsal habenular nuclei of zebrafish, homologous to the medial nuclei of mammals, as recent work has revealed new information about the signaling pathways that regulate their formation. Additionally, the zebrafish dorsal habenulae have become a valuable model for probing how left-right differences are established in a vertebrate brain. Sonic hedgehog, fibroblast growth factors and Wingless-INT proteins are all involved in the generation of progenitor cells and ultimately, along with Notch signaling, influence habenular neurogenesis and left-right asymmetry. Intriguingly, a genetic network has emerged that leads to the differentiation of dorsal habenular neurons and, through localized chemokine signaling, directs the posterior outgrowth of their newly emerging axons towards their postsynaptic target, the midbrain interpeduncular nucleus.

KEYWORDS:

Fasciculus retroflexus; Habenula; Interpeduncular nucleus; Left-right asymmetry

PMID:
29107475
PMCID:
PMC5920772
[Available on 2019-06-01]
DOI:
10.1016/j.semcdb.2017.10.007

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center