Format

Send to

Choose Destination
Neurobiol Aging. 2018 Jan;61:169-176. doi: 10.1016/j.neurobiolaging.2017.09.024. Epub 2017 Oct 5.

Anxiety-like behavior as an early endophenotype in the TgF344-AD rat model of Alzheimer's disease.

Author information

1
Department of Psychology, University of New Mexico, Albuquerque, NM, USA. Electronic address: pentkowski@unm.edu.
2
Department of Psychology, University of New Mexico, Albuquerque, NM, USA.
3
Department of Psychology, University of New Mexico, Albuquerque, NM, USA. Electronic address: bnjclark@unm.edu.

Abstract

Alzheimer's disease (AD) is characterized by progressive cognitive decline and the presence of aggregates of amyloid beta (plaques) and hyperphosphorylated tau (tangles). Early diagnosis through neuropsychological testing is difficult due to comorbidity of symptoms between AD and other types of dementia. As a result, there is a need to identify the range of behavioral phenotypes expressed in AD. In the present study, we utilized a transgenic rat (TgF344-AD) model that bears the mutated amyloid precursor protein as well as presenilin-1 genes, resulting in progressive plaque and tangle pathogenesis throughout the cortex. We tested young adult male and female TgF344-AD rats in a spatial memory task in the Morris water maze and for anxiety-like behavior in the elevated plus-maze. Results indicated that regardless of sex, TgF344-AD rats exhibited increased anxiety-like behavior in the elevated plus-maze, which occurred without significant deficits in the spatial memory. Together, these results indicate that enhanced anxiety-like behavior represents an early-stage behavioral marker in the TgF344-AD rat model.

KEYWORDS:

Anxiety; Defensive behavior; Dementia; Memory; Spatial behavior; Transgenic model

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center