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Cereb Cortex. 2018 Aug 1;28(8):2834-2845. doi: 10.1093/cercor/bhx162.

Developmental Changes in the Integration of Affective and Cognitive Corticostriatal Pathways are Associated with Reward-Driven Behavior.

Author information

1
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
2
Center for the Neural Basis of Cognition, Pittsburgh, PA, USA.
3
Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA.
4
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
5
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.

Abstract

The relative influence of affective and cognitive processes on behavior is increasingly understood to transform through development, from adolescence into adulthood, but the neuroanatomical mechanisms underlying this change are not well understood. We analyzed diffusion magnetic resonance imaging in 115 10- to 28-year-old participants to identify convergent corticostriatal projections from cortical systems involved in affect and cognitive control and determined the age-related differences in their relative structural integrity. Results indicate that the relative integrity of affective projections, in relation to projections from cognitive control systems, decreases with age and is positively associated with reward-driven task performance. Together, these findings provide new evidence that developmental differences in the integration of corticostriatal networks involved in affect and cognitive control underlie known developmental decreases in the propensity for reward-driven behavior into adulthood.

PMID:
29106535
PMCID:
PMC6041988
[Available on 2019-08-01]
DOI:
10.1093/cercor/bhx162

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