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Angew Chem Int Ed Engl. 2017 Dec 22;56(52):16515-16520. doi: 10.1002/anie.201707043. Epub 2017 Dec 4.

Radical Copolymerization of Vinyl Ethers and Cyclic Ketene Acetals as a Versatile Platform to Design Functional Polyesters.

Author information

1
Aix Marseille Univ, CNRS, Institut de Chimie Radicalaire, UMR 7273, Marseille, France.
2
Institut Galien Paris-Sud, Univ Paris-Sud, UMR CNRS 8612, Faculté de Pharmacie, Châtenay-Malabry, France.
3
Laboratoire de recherche vasculaire translationnelle, INSERM 1148, University Paris 13 &, University Paris Diderot, Paris, France.
4
Aix Marseille Univ, CNRS, Centrale Marseille, UMR 7313, iSm2, Marseille, France.

Abstract

Free-radical copolymerization of cyclic ketene acetals (CKAs) and vinyl ethers (VEs) was investigated as an efficient yet simple approach for the preparation of functional aliphatic polyesters. The copolymerization of CKA and VE was first predicted to be quasi-ideal by DFT calculations. The theoretical prediction was experimentally confirmed by the copolymerization of 2-methylene-1,3-dioxepane (MDO) and butyl vinyl ether (BVE), leading to rMDO =0.73 and rBVE =1.61. We then illustrated the versatility of this approach by preparing different functional polyesters: 1) copolymers functionalized by fluorescent probes; 2) amphiphilic copolymers grafted with poly(ethylene glycol) (PEG) side chains able to self-assemble into PEGylated nanoparticles; 3) antibacterial films active against Gram-positive and Gram-negative bacteria (including a multiresistant strain); and 4) cross-linked bioelastomers with suitable properties for tissue engineering applications.

KEYWORDS:

DFT calculations; biomaterials; copolymerization; cyclic ketene acetals; functional polyesters

PMID:
29105983
DOI:
10.1002/anie.201707043

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