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Int J Cancer. 2018 Apr 15;142(8):1528-1535. doi: 10.1002/ijc.31141. Epub 2017 Nov 21.

Generational shift in melanoma incidence and mortality in Queensland, Australia, 1995-2014.

Aitken JF1,2,3, Youlden DR1,4, Baade PD1,5, Soyer HP6,7, Green AC8,9,10, Smithers BM11,12.

Author information

1
Cancer Council Queensland, Brisbane, QLD, Australia.
2
Institute for Resilient Regions, University of Southern Queensland, Brisbane, QLD, Australia.
3
School of Public Health and Social Work, Queensland University of Technology, Brisbane, QLD, Australia.
4
Menzies Health Institute, Griffith University, Gold Coast, QLD, Australia.
5
School of Mathematical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
6
Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Brisbane, QLD, Australia.
7
Department of Dermatology, Princess Alexandra Hospital, Brisbane, QLD, Australia.
8
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
9
CRUK Manchester Institute and Division of Musculoskeletal & Dermatological Sciences, University of Manchester, Manchester, United Kingdom.
10
Australian Skin and Skin Cancer Research Centre, Brisbane, QLD, Australia.
11
Queensland Melanoma Project, Princess Alexandra Hospital, Brisbane, QLD, Australia.
12
Discipline of Surgery, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.

Abstract

Public campaigns encouraging sun protection for skin cancer prevention began in Queensland, Australia, in the early 1980s. We examined recent trends to assess whether earlier evidence of stabilizing melanoma incidence in young people has persisted. Anonymized incidence and mortality data for in situ and invasive melanoma for the 20 years 1995-2014 were obtained from the Queensland Cancer Registry. Time trends were analyzed using JoinPoint regression. Birth cohort patterns were assessed using age-period-cohort models. Melanoma incidence in Queensland remains the highest recorded in the world (age-standardized incidence of invasive melanoma (2010-2014) = 72/100,000/annum). Over the 20-year period, incidence of in situ melanoma increased in all age groups. Incidence of both thin (≤1 mm) and thick (>1 mm) invasive melanoma was either stable or decreased in people under 60, while it increased in those aged 60 and above, particularly in men. Age-period-cohort analysis revealed decreasing age-specific incidence of invasive melanoma under 40 years of age, beginning with the birth cohort born around the mid-1960s, with steepest falls for those born around 1980 and later. Age-specific incidence was stable between 40 and 59 years of age from the 1945 birth cohort onwards. Melanoma mortality over the period was stable or decreased in all groups except in men aged 60 or over. These findings are evidence of real advances in the prevention and early detection of invasive melanoma in this very high-risk population. They make a compelling case for continued public health efforts to reduce the burden of melanoma in susceptible populations.

KEYWORDS:

Queensland; incidence; melanoma; mortality; trends

PMID:
29105744
DOI:
10.1002/ijc.31141
[Indexed for MEDLINE]
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