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J Biomater Appl. 2018 Mar;32(8):1119-1126. doi: 10.1177/0885328217739451. Epub 2017 Nov 6.

Dynamic mechanical behaviour of nanoparticle loaded biodegradable PVA films for vaginal drug delivery.

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1 70382 School of Pharmacy, University of Waterloo , Waterloo, Ontario, Canada.
2 College of Pharmacy, Rady Faculty of Health Sciences, 8664 University of Manitoba , Winnipeg, Manitoba, Canada.


In this study, we investigated the viscoelastic and mechanical behaviour of polyvinyl alcohol films formulated along with carrageenan, plasticizing agents (polyethylene glycol and glycerol), and when loaded with nanoparticles as a model for potential applications as microbicides. The storage modulus, loss modulus and glass transition temperature were determined using a dynamic mechanical analyzer. Films fabricated from 2% to 5% polyvinyl alcohol containing 3 mg or 5 mg of fluorescently labeled nanoparticles were evaluated. The storage modulus and loss modulus values of blank films were shown to be higher than the nanoparticle-loaded films. Glass transition temperature determined using the storage modulus, and loss modulus was between 40-50℃ and 35-40℃, respectively. The tensile properties evaluated showed that 2% polyvinyl alcohol films were more elastic but less resistant to breaking compared to 5% polyvinyl alcohol films (2% films break around 1 N load and 5% films break around 7 N load). To our knowledge, this is the first study to evaluate the influence of nanoparticle and film composition on the physico-mechanical properties of polymeric films for vaginal drug delivery.


Poly (vinyl alcohol); dynamic mechanical analysis; glass transition temperature; modulus; nanoparticles; thermal stability


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