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Neuron. 2017 Dec 6;96(5):1127-1138.e4. doi: 10.1016/j.neuron.2017.10.017. Epub 2017 Nov 2.

Local Order within Global Disorder: Synaptic Architecture of Visual Space.

Author information

1
Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL 33458, USA.
2
Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL 33458, USA; Integrative Biology and Neuroscience Graduate Program, International Max Planck Research School for Brain and Behavior, Florida Atlantic University, Jupiter, Florida, USA.
3
Max Planck Florida Institute for Neuroscience, 1 Max Planck Way, Jupiter, FL 33458, USA. Electronic address: david.fitzpatrick@mpfi.org.

Abstract

Substantial evidence at the subcellular level indicates that the spatial arrangement of synaptic inputs onto dendrites could play a significant role in cortical computations, but how synapses of functionally defined cortical networks are arranged within the dendrites of individual neurons remains unclear. Here we assessed one-dimensional spatial receptive fields of individual dendritic spines within individual layer 2/3 neuron dendrites. Spatial receptive field properties of dendritic spines were strikingly diverse, with no evidence of large-scale topographic organization. At a fine scale, organization was evident: neighboring spines separated by less than 10 μm shared similar spatial receptive field properties and exhibited a distance-dependent correlation in sensory-driven and spontaneous activity patterns. Fine-scale dendritic organization was supported by the fact that functional groups of spines defined by dimensionality reduction of receptive field properties exhibited non-random dendritic clustering. Our results demonstrate that functional synaptic clustering is a robust feature existing at a local spatial scale. VIDEO ABSTRACT.

KEYWORDS:

dendritic spine; synaptic cluster; visual cortex

PMID:
29103806
PMCID:
PMC5868972
DOI:
10.1016/j.neuron.2017.10.017
[Indexed for MEDLINE]
Free PMC Article

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