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Lasers Med Sci. 2018 Feb;33(2):295-304. doi: 10.1007/s10103-017-2367-7. Epub 2017 Nov 4.

Laser acupuncture-induced analgesic effect and molecular alterations in an incision pain model: a comparison with electroacupuncture-induced effects.

Zeng YJ1, Lin YH2, Wang YC3, Chang JH1,4, Wu JH5, Hsu SF6,7,8, Tsai SY4, Lin CH2,3, Wen YR9,10,11,12,13.

Author information

1
Graduate Institute of Clinical Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
2
Microelectronic and Optoelectronic Engineering Department of Electronic Engineering, National Yunlin University of Science and Technology, Yunlin, Taiwan.
3
Department of Electronic Engineering, National Yunlin University of Science and Technology, Yunlin, Taiwan.
4
Department of Anesthesiology, China Medical University Hospital, No. 2, Yuh-Der Rd, North District, 40447, Taichung, Taiwan.
5
Department of Biomedical Engineering, Ming Chuan University, Taipei City, Taiwan.
6
Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
7
Department of Acupuncture, China Medical University Hospital Taipei Branch, Taipei, Taiwan.
8
Acupuncture Research Center, China Medical University, Taichung, Taiwan.
9
Department of Anesthesiology, China Medical University Hospital, No. 2, Yuh-Der Rd, North District, 40447, Taichung, Taiwan. yr.wen@yahoo.com.tw.
10
Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung, Taiwan. yr.wen@yahoo.com.tw.
11
Acupuncture Research Center, China Medical University, Taichung, Taiwan. yr.wen@yahoo.com.tw.
12
Department of Anesthesiology, School of Medicine, China Medical University, Taichung, Taiwan. yr.wen@yahoo.com.tw.
13
Center for Pain Research and Management, Department of Anesthesiology, School of Medicine, China Medical University, Taichung, Taiwan. yr.wen@yahoo.com.tw.

Abstract

Low-level laser acupuncture (LLLA) produces photobiomodulation through acupuncture point and is an alternative to low-level laser therapy. Although the analgesic effect of LLLA on chronic pain has been proven, its effect on acute postincisional pain has yet to be investigated. A plantar incision (PI) model was used to mimic human postsurgical pain. Male adult rats received GaAlAs laser irradiation at the right ST36 acupoint immediately after operation and on the following 4 days. Three laser treatment groups (two red laser groups with a 30- or 15-min treatment duration and one 30-min near-infrared laser group) were compared with sham LLLA and naive groups and an electroacupuncture (EA) group (separate study). Behavioral withdrawal thresholds of both hind paws were measured before and after incision. Expression of mitogen-activated protein kinases (p-ERK and p-p38), inducible nitric oxide synthase (iNOS), and tumor necrosis factor (TNF) in the spinal cord was analyzed. All three LLLA treatments attenuated post-PI tactile allodynia in the ipsilateral paw, but only the 30-min red laser treatment affected the contralateral paw and had similar efficacy to that of EA. All laser treatments barely reduced heat hyperalgesia in both hind paws. At 3 days after PI, the 30-min red laser group showed reversed increases of PI-induced p-ERK, p-p38, and iNOS but not TNF expression in the spinal cord. Repetitive LLLA treatments ameliorated PI-induced mechanical pain. The inhibition of multiple sensitization signals highlights the unique clinical role of LLLA. Thus, LLLA is an alternative to EA as an adjuvant for postoperative pain control.

KEYWORDS:

Laser acupuncture; MAPK; Postoperative pain; TNF; iNOS

PMID:
29103083
PMCID:
PMC5803293
DOI:
10.1007/s10103-017-2367-7
[Indexed for MEDLINE]
Free PMC Article

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