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Cell. 2017 Nov 2;171(4):736-737. doi: 10.1016/j.cell.2017.10.030.

A Missing Link to Vitamin B12 Metabolism.

Author information

1
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
2
Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
3
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA. Electronic address: Jason.Locasale@duke.edu.

Abstract

Nearly 3% of the human population carries bi-allelic loss-of-function variants in the gene encoding CLYBL. While largely healthy, these individuals exhibit reduced circulating vitamin B12 levels. In this issue of Cell, Shen and colleagues uncover the metabolic role of CLYBL, linking its function to B12 metabolism and the immunomodulatory metabolite, itaconate.

PMID:
29100069
DOI:
10.1016/j.cell.2017.10.030

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