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Pathog Dis. 2017 Dec 29;75(9). doi: 10.1093/femspd/ftx115.

Draft genome sequence of the Wolbachia endosymbiont of Wuchereria bancrofti wWb.

Author information

1
Institute for Genome Sciences, University of Maryland, Baltimore, MD 21201, USA.
2
Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA.
3
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH 44106, USA.
4
Eck Institute for Global Health, University of Notre Dame, South Bend, IN 46556, USA.

Abstract

The draft genome assembly of the Wolbachia endosymbiont of Wuchereria bancrofti (wWb) consists of 1060 850 bp in 100 contigs and contains 961 ORFs, with a single copy of the 5S rRNA, 16S rRNA and 23S rRNA and each of the 34 tRNA genes. Phylogenetic core genome analyses show wWb to cluster with other strains in supergroup D of the Wolbachia phylogeny, while being most closely related to the Wolbachia endosymbiont of Brugia malayi strain TRS (wBm). The wWb and wBm genomes share 779 orthologous clusters with wWb having 101 unclustered genes and wBm having 23 unclustered genes. The higher number of unclustered genes in the wWb genome likely reflects the fragmentation of the draft genome.

KEYWORDS:

Wolbachia; Wuchereria bancrofti; endosymbiont; genomics; lymphatic filariasis; nematode

PMID:
29099918
PMCID:
PMC5827699
DOI:
10.1093/femspd/ftx115
[Indexed for MEDLINE]
Free PMC Article

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