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Int J Mol Sci. 2017 Nov 3;18(11). pii: E2325. doi: 10.3390/ijms18112325.

Estrogen Effects on Wound Healing.

Horng HC1,2,3, Chang WH4,5,6, Yeh CC7,8,9, Huang BS10,11,12, Chang CP13,14, Chen YJ15,16,17, Tsui KH18,19,20, Wang PH21,22,23,24.

Author information

1
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.
2
Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.
3
Institute of BioMedical Informatics, National Yang-Ming University, Taipei 112, Taiwan. hchorng@vghtpe.gov.tw.
4
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.
5
Department of Nursing, Taipei Veterans General Hospital, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.
6
Department of Nursing, National Yang-Ming University, Taipei 112, Taiwan. whchang@vghtpe.gov.tw.
7
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. ccyeh39@gmail.com.
8
Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. ccyeh39@gmail.com.
9
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. ccyeh39@gmail.com.
10
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. benshianhuang@gmail.com.
11
Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. benshianhuang@gmail.com.
12
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. benshianhuang@gmail.com.
13
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. jpchang2@vghtpe.gov.tw.
14
Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. jpchang2@vghtpe.gov.tw.
15
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. chenyj@vghtpe.gov.tw.
16
Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. chenyj@vghtpe.gov.tw.
17
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. chenyj@vghtpe.gov.tw.
18
Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. khtsui60@gmail.com.
19
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan. khtsui60@gmail.com.
20
Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung County 900, Taiwan. khtsui60@gmail.com.
21
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan. phwang@vghtpe.gov.tw.
22
Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei 112, Taiwan. phwang@vghtpe.gov.tw.
23
Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan. phwang@vghtpe.gov.tw.
24
Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan. phwang@vghtpe.gov.tw.

Abstract

Wound healing is a physiological process, involving three successive and overlapping phases-hemostasis/inflammation, proliferation, and remodeling-to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing.

KEYWORDS:

estrogen; estrogen receptor; wound healing

PMID:
29099810
PMCID:
PMC5713294
DOI:
10.3390/ijms18112325
[Indexed for MEDLINE]
Free PMC Article

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