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Anesth Analg. 2018 May;126(5):1747-1754. doi: 10.1213/ANE.0000000000002620.

Colloids and the Microcirculation.

He H1, Liu D1, Ince C2,3.

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From the Department of Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.
Department of Translational Physiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Department of Intensive Care, Erasmus MC, University Hospital Rotterdam, Rotterdam, the Netherlands.


Colloid solutions have been advocated for use in treating hypovolemia due to their expected effect on improving intravascular retention compared with crystalloid solutions. Because the ultimate desired effect of fluid resuscitation is the improvement of microcirculatory perfusion and tissue oxygenation, it is of interest to study the effects of colloids and crystalloids at the level of microcirculation under conditions of shock and fluid resuscitation, and to explore the potential benefits of using colloids in terms of recruiting the microcirculation under conditions of hypovolemia. This article reviews the physiochemical properties of the various types of colloid solutions (eg, gelatin, dextrans, hydroxyethyl starches, and albumin) and the effects that they have under various conditions of hypovolemia in experimental and clinical scenarios.

[Indexed for MEDLINE]

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