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J Neurosurg. 2018 Oct;129(4):854-860. doi: 10.3171/2017.5.JNS17195. Epub 2017 Nov 3.

Rupture prediction of intracranial aneurysms: a nationwide matched case-control study of hemodynamics at the time of diagnosis.

Author information

1
1Faculty of Health, UiT The Arctic University of Norway, Tromsø.
2
2Department of Neurosurgery, University Hospital of Northern Norway, Tromsø.
3
3Simula Research Laboratory, Oslo.
4
4Department of Neurosurgery, Haukeland University Hospital, Bergen; and.
5
5Department of Clinical Medicine, University of Bergen, Norway.

Abstract

The authors used computer simulation to investigate the hemodynamics in 36 unruptured aneurysms on the first day the lesions were discovered; 12 of them later ruptured. Knowledge about any differences in hemodynamics at this early stage improves predictions about which patients will get a subarachnoid hemorrhage-a dangerous bleeding in the brain-and helps decide which patients should be treated in advance to avoid the bleeding.

KEYWORDS:

ACoA = anterior communicating artery; CFD = computational fluid dynamics; IA = intracranial aneurysm; ICA = internal carotid artery; ICI = inflow concentration index; IQR = interquartile range; LSA = low shear area; MCA = middle cerebral artery; OSI = oscillatory shear index; PCoA = posterior communicating artery; PHASES = population; PLc = pressure loss coefficient; SAH = subarachnoid hemorrhage; VDR = viscous dissipation ratio; WSS = wall shear stress; computational fluid dynamics; hemodynamics; hypertension, age, size of aneurysm, earlier SAH from another aneurysm, site of aneurysm; intracranial aneurysm; rupture; subarachnoid hemorrhage; vascular disorders

PMID:
29099302
DOI:
10.3171/2017.5.JNS17195

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