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Int J Mol Sci. 2017 Nov 2;18(11). pii: E2312. doi: 10.3390/ijms18112312.

Actions of Brain-Derived Neurotrophic Factor and Glucocorticoid Stress in Neurogenesis.

Author information

1
Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-8555, Japan. numakawa.yyrmk@gmail.com.
2
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Tokyo 187-8551, Japan. numakawa.yyrmk@gmail.com.
3
Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-8555, Japan. harukiodaka@ruri.waseda.jp.
4
Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, Tokyo 169-8050, Japan. harukiodaka@ruri.waseda.jp.
5
Department of Biomedical Chemistry, School of Science and Technology, Kwansei Gakuin University, Sanda City, Hyogo 662-8501, Japan. adachi@kwansei.ac.jp.

Abstract

Altered neurogenesis is suggested to be involved in the onset of brain diseases, including mental disorders and neurodegenerative diseases. Neurotrophic factors are well known for their positive effects on the proliferation/differentiation of both embryonic and adult neural stem/progenitor cells (NSCs/NPCs). Especially, brain-derived neurotrophic factor (BDNF) has been extensively investigated because of its roles in the differentiation/maturation of NSCs/NPCs. On the other hand, recent evidence indicates a negative impact of the stress hormone glucocorticoids (GCs) on the cell fate of NSCs/NPCs, which is also related to the pathophysiology of brain diseases, such as depression and autism spectrum disorder. Furthermore, studies including ours have demonstrated functional interactions between neurotrophic factors and GCs in neural events, including neurogenesis. In this review, we show and discuss relationships among the behaviors of NSCs/NPCs, BDNF, and GCs.

KEYWORDS:

BDNF; glucocorticoids; intracellular signaling; neural stem cells; neurogenesis

PMID:
29099059
PMCID:
PMC5713281
DOI:
10.3390/ijms18112312
[Indexed for MEDLINE]
Free PMC Article

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