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Adv Exp Med Biol. 2017;1000:333-353. doi: 10.1007/978-981-10-4304-8_18.

Exosomes Mediate the Beneficial Effects of Exercise.

Author information

1
Institute for Department of Cardiovascular Surgery & Cardiovascular Science, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China. yangxin_li@yahoo.com.
2
Institute for Department of Cardiovascular Surgery & Cardiovascular Science, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.
3
Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, People's Republic of China.
4
Department of Cardiology, ChangZheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
5
College of Pharmacy & Health Sciences, Texas Southern University, Houston, TX, USA.
6
Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, Jiangsu, 215123, People's Republic of China.

Abstract

It is known that moderate exercise can prevent the development of cardiovascular diseases, but the exact molecular mechanisms mediating cardioprotective effect of exercise remain unknown. Emerging evidence suggests that exercise has great impact on the biogenesis of exosomes, which have been found in both interstitial fluid and circulation, and play important roles in cellular communication. Exosomes carry functional molecules such as mRNAs, microRNA, and specific proteins, which can be used in the early diagnosis and targeted therapy of a variety of diseases. Our review focus on the current knowledge on exosome production, secretion, uptake and how exercise influence exosome content. We also highlight recent research development in exosome based approach for cardiac repair.

KEYWORDS:

Beneficial effect; Cardiovascular diseases; Exercise; Exosome; HSP; miRNA

PMID:
29098629
DOI:
10.1007/978-981-10-4304-8_18
[Indexed for MEDLINE]

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