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Sci Rep. 2017 Nov 6;7(1):14602. doi: 10.1038/s41598-017-15109-x.

Task-Correlated Cortical Asymmetry and Intra- and Inter-Hemispheric Separation.

Author information

1
Department of Child and Adolescent Psychiatry, New York University School of Medicine, New York, USA. yaniv_c_j@yahoo.com.
2
Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, USA. yaniv_c_j@yahoo.com.
3
Department of Child and Adolescent Psychiatry, New York University School of Medicine, New York, USA. Donald.wilson@nyumc.org.
4
Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, USA. Donald.wilson@nyumc.org.

Abstract

Cerebral lateralization is expressed at both the structural and functional levels, and can exist as either a stable characteristic or as a dynamic feature during behavior and development. The anatomically relatively simple olfactory system demonstrates lateralization in both human and non-human animals. Here, we explored functional lateralization in both primary olfactory cortex - a region critical for odor memory and perception- and orbitofrontal cortex (OFC) - a region involved in reversal learning- in rats performing an odor learning and reversal task. We find significant asymmetry in both olfactory and orbitofrontal cortical odor-evoked activity, which is expressed in a performance- and task-dependent manner. The emergence of learning-dependent asymmetry during reversal learning was associated with decreased functional connectivity both between the bilateral OFC and between the OFC-olfactory cortex. The results suggest an inter-hemispheric asymmetry and olfactory cortical functional separation that may allow multiple, specialized processing circuits to emerge during a reversal task requiring behavioral flexibility.

PMID:
29097760
PMCID:
PMC5668373
DOI:
10.1038/s41598-017-15109-x
[Indexed for MEDLINE]
Free PMC Article

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