Format

Send to

Choose Destination
Cancer Lett. 2018 Jan 28;413:11-22. doi: 10.1016/j.canlet.2017.10.041. Epub 2017 Oct 31.

Apigenin: A dietary flavonoid with diverse anticancer properties.

Author information

1
Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000, Zagreb, Croatia.
2
Molecular Toxicology Unit, Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, 10000, Zagreb, Croatia.
3
Mutagenesis Unit, Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, 10000, Zagreb, Croatia.
4
Department of Diagnostic and Interventional Radiology, Clinical Hospital Merkur, Zajčeva 19, 10000, Zagreb, Croatia.
5
Mutagenesis Unit, Institute for Medical Research and Occupational Health, Ksaverska Cesta 2, 10000, Zagreb, Croatia. Electronic address: vgaraj@imi.hr.

Abstract

Apigenin is a natural flavonoid found in several dietary plant foods such as vegetables and fruits. A large number of studies conducted over the past years have shown that this particular natural compound has potential antioxidant, anti-inflammatory, and anticancer properties. Therefore, apigenin has generated a great deal of interest as a possible chemotherapeutic modality due to its low intrinsic toxicity and remarkable effects on normal versus cancerous cells, compared with other structurally related flavonoids. Here, we review its role in anticancer research, as well as several cancer signalling pathways, including MAPK, PI3K/Akt and NF-κB pathways, and their specific role in different cancer types. Based on the available literature, the beneficial effects of apigenin as a future anticancer modality are promising but they require further in vitro and in vivo studies to enable its translation from bench to bedside.

KEYWORDS:

Anticancer activity; Apigenin; Apoptosis; Cell cycle arrest; Signalling pathways

PMID:
29097249
DOI:
10.1016/j.canlet.2017.10.041
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center