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Toxicol Lett. 2018 Feb;283:52-57. doi: 10.1016/j.toxlet.2017.10.023. Epub 2017 Oct 31.

The organophosphate malathion disturbs gut microbiome development and the quorum-Sensing system.

Author information

1
NIH West Coast Metabolomics Center, University of California, Davis, CA 95616, United States; Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
2
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
3
Department of Environmental Health Science, University of Georgia, Athens, 30602, Georgia; Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.
4
Department of Environmental Health Science, University of Georgia, Athens, 30602, Georgia.
5
Department of Population Health and Pathobiology, North Carolina State University, Raleigh, NC 27607, United States.
6
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States. Electronic address: kunlu@unc.edu.

Abstract

The gut microbiome has tremendous potential to impact health and disease. Various environmental toxicants, including insecticides, have been shown to alter gut microbiome community structures. However, the mechanism that compositionally and functionally regulates gut microbiota remains unclear. Quorum sensing is known to modulate intra- and interspecies gene expression and coordinate population responses. It is unknown whether quorum sensing is disrupted when environmental toxicants cause perturbations in the gut microbiome community structure. To reveal the response of the quorum-sensing system to environmental exposure, we use a combination of Illumina-based 16S rRNA gene amplicon and shotgun metagenome sequencing to examine the impacts of a widely used organophosphate insecticide, malathion, on the gut microbiome trajectory, quorum sensing system and behaviors related to quorum sensing, such as motility and pathogenicity. Our results demonstrated that malathion perturbed the gut microbiome development, quorum sensing and quorum sensing related behaviors. These findings may provide a novel mechanistic understanding of the role of quorum-sensing in the gut microbiome toxicity of malathion.

KEYWORDS:

Gut microbiome toxicity; Malathion; Quorum sensing

PMID:
29097220
DOI:
10.1016/j.toxlet.2017.10.023
[Indexed for MEDLINE]

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