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Arch Physiol Biochem. 2018 Oct;124(4):292-299. doi: 10.1080/13813455.2017.1396348. Epub 2017 Nov 2.

Effects of chronic aspartame consumption on MPTP-induced Parkinsonism in male and female mice.

Author information

1
a Department of Medical Physiology, Faculty of Medicine , Cairo University , Cairo , Egypt.
2
b Department of Medical Education , School of Medicine, California University of Science & Medicine , San Bernardino , CA , USA.
3
c Department of Anatomy, Faculty of Medicine , Cairo University , Cairo , Egypt.
4
d Department of Biochemistry, Faculty of Medicine , Cairo University , Cairo , Egypt.

Abstract

BACKGROUND:

Parkinson's disease is a progressive neurodegenerative disorder. Aspartame (l-aspartyl-l-phenylalanine methyl ester), a low calorie sweetener used in foods and beverages.

OBJECTIVES:

This study investigated the effect of chronic aspartame intake on Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

METHOD:

Forty-eight mice (24 males and 24 females): control, aspartame, MPTP, and aspartame + MPTP groups tested by Y-maze, stepping, forced swimming and olfactory preference tests. Brain tissues examined for dopamine content, tyrosine hydroxylase, inducible nitric oxide synthase (iNOS), glutathione peroxidase, phosphorylated tau and α-synuclein protein. Histopathological evaluation of brain sections at the level of basal ganglia was done.

RESULTS:

Decreased dopamine content, tyrosine hydroxylase expression, glutathione peroxidase expression and increased iNOS, tau and α-synuclein expression in groups received aspartame, MPTP or both agents simultaneously in both males and females group.

CONCLUSIONS:

Increased dopaminergic degeneration and complications with chronic aspartame consumption and more injury in male groups.

KEYWORDS:

MPTP; Parkinsonism; aspartame; behaviour; memory

PMID:
29096532
DOI:
10.1080/13813455.2017.1396348
[Indexed for MEDLINE]

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