Send to

Choose Destination
Neuron. 2017 Nov 1;96(3):667-679. doi: 10.1016/j.neuron.2017.10.015.

Compartmentalized Signaling in Neurons: From Cell Biology to Neuroscience.

Author information

Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel.
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, UK; Discoveries Centre for Regenerative and Precision Medicine at UCL, London WC1N 3BG, UK; UK Dementia Research Institute at UCL, London WC1E 6BT, UK.
Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:


Neurons are the largest known cells, with complex and highly polarized morphologies. As such, neuronal signaling is highly compartmentalized, requiring sophisticated transfer mechanisms to convey and integrate information within and between sub-neuronal compartments. Here, we survey different modes of compartmentalized signaling in neurons, highlighting examples wherein the fundamental cell biological processes of protein synthesis and degradation, membrane trafficking, and organelle transport are employed to enable the encoding and integration of information, locally and globally within a neuron. Comparisons to other cell types indicate that neurons accentuate widely shared mechanisms, providing invaluable models for the compartmentalization and transfer mechanisms required and used by most eukaryotic cells.


axonal transport; dynein; importin; kinesin; local translation; mRNA localization; microtubule; neurotrophin; receptor tyrosine kinase; subcellular

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center