Format

Send to

Choose Destination
J Perinatol. 2018 Jan;38(1):80-85. doi: 10.1038/jp.2017.164. Epub 2017 Nov 2.

Prospective research on infants with mild encephalopathy: the PRIME study.

Author information

1
Mahidol University, Bangkok, Thailand.
2
University of Texas Southwestern Medical Center, Dallas, TX, USA.
3
McGill University Health Center, Montreal, QC, Canada.
4
Brown University, Rhode Island, Providence, RI, USA.
5
Wayne State University, Detroit, MI, USA.
6
Imperial College, London, UK.
7
Center for Perinatal Research, Nationwide Children's Hospital-The Ohio State University, Columbus, OH, USA.

Abstract

OBJECTIVE:

To determine short-term outcomes of infants with evidence of hypoxia-ischemia at birth and classified as mild neonatal encephalopathy (NE) at <6 h of age.

STUDY DESIGN:

Prospective multicenter study. Mild NE was defined as ⩾1 abnormal category in modified Sarnat score. Primary outcome was any abnormality on early amplitude integrated electroencephalogram (aEEG) or seizures, abnormal brain magnetic resonance imaging (MRI) or neurological exam at discharge.

RESULTS:

A total of 54/63 (86%) of enrolled infants had data on components of the primary outcome, which was abnormal in 28/54 (52%): discontinuous aEEG (n=4), MRI (n=9) and discharge exam (n=22). Abnormal tone and/or incomplete Moro were the most common findings. MRI abnormalities were confined to cerebral cortex but two infants had basal ganglia and/or thalamus involvement. The 18 to 24 months follow-up is ongoing.

CONCLUSIONS:

A larger than expected proportion of mild NE infants with abnormal outcomes was observed. Future research should evaluate safety and efficacy of neuroprotection for mild NE.

PMID:
29095433
DOI:
10.1038/jp.2017.164
Free full text

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for Spiral, Imperial College Digital Repository
Loading ...
Support Center