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Nucleus. 2018 Jan 1;9(1):142-148. doi: 10.1080/19491034.2017.1395542.

Nuclear pore complexes as hubs for gene regulation.

Author information

1
a Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program, NCI-Designated Cancer Center , 10901 N. Torrey Pines Road, La Jolla , CA , United States.

Abstract

Nuclear pore complexes (NPCs), the channels connecting the nucleus with the cytoplasm, are the largest protein structures of the nuclear envelope. In addition to their role in regulating nucleocytoplasmic transport, increasing evidence shows that these multiprotein structures play central roles in the regulation of gene activity. In light of recent discoveries, NPCs are emerging as scaffolds that mediate the regulation of specific gene sets at the nuclear periphery. The function of NPCs as genome organizers and hubs for transcriptional regulation provides additional evidence that the compartmentalization of genes and transcriptional regulators within the nuclear space is an important mechanism of gene expression regulation.

KEYWORDS:

Muscle; Nuclear pore complex; Nucleoporin; gene expression; nuclear envelope; nuclear transport; transcription

PMID:
29095096
PMCID:
PMC5973259
DOI:
10.1080/19491034.2017.1395542
[Indexed for MEDLINE]
Free PMC Article

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