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Adipocyte. 2018 Jan 2;7(1):45-48. doi: 10.1080/21623945.2017.1388971. Epub 2017 Nov 2.

Elucidating the role of adipose tissue secreted factors in malignant transformation.

Author information

1
a Department of Pharmacology and Toxicology , Michigan State University , East Lansing , MI , USA.

Abstract

Although there is a growing number of incidences of obesity and obesity-linked cancers, how excess adiposity actually causes cancer has not been fully explained. Our previous study showed that removal of visceral adipose tissue significantly reduced the number of ultraviolet radiation (UVR)-initiated, high-fat diet-promoted skin cancers. This commentary focuses on our recently published study (Chakraborty, et al., 2017) which demonstrated that fibroblast growth factor-2 (FGF2) released from visceral adipose tissue is a key factor in the malignant transformation of epithelial cells. Within this commentary we have provided additional interpretations and new data in support of the role of FGF2 in adiposity-associated tumorigenesis.

KEYWORDS:

FGF2; adiposity; breast cancer; cancer; obesity; skin cancer; visceral fat

PMID:
29095087
PMCID:
PMC5915015
DOI:
10.1080/21623945.2017.1388971
[Indexed for MEDLINE]
Free PMC Article

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