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J Org Chem. 2017 Dec 1;82(23):12771-12777. doi: 10.1021/acs.joc.7b02019. Epub 2017 Nov 14.

Bimetallic Cobalt-Rhodium Nanoparticle-Catalyzed Reductive Amination of Aldehydes with Nitroarenes Under Atmospheric Hydrogen.

Author information

1
Department of Chemistry, College of Natural Sciences, Seoul National University , Seoul 08826, Korea.

Abstract

A cobalt-rhodium heterobimetallic nanoparticle (Co2Rh2/C)-catalyzed tandem reductive amination of aldehydes with nitroaromatics to sec-amines has been developed. The tandem reaction proceeds without any additives under mild conditions (1 atm H2 and 25 °C). This procedure can be scaled up to the gram scale, and the catalyst can be reused more than six times without loss of activity.

PMID:
29094946
DOI:
10.1021/acs.joc.7b02019

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