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Child Dev. 2017 Nov 2. doi: 10.1111/cdev.12987. [Epub ahead of print]

Sometimes It's Good to be Short: The Serotonin Transporter Gene, Positive Parenting, and Adolescent Depression.

Author information

1
University of Melbourne.
2
Murdoch Childrens Research Institute.
3
Deakin University.
4
Oregon Research Institute.
5
Monash University.
6
University of Oregon.

Abstract

In threatening environments, the short (S) allele of 5-HTTLPR is proposed to augment risk for depression. However, it is unknown whether 5-HTTLPR variation increases risk for depression in environments of deprivation, lacking positive or nurturant features. Two independent longitudinal studies (n = 681 and 176, respectively) examined whether 5-HTTLPR moderated associations between low levels of positive parenting at 11-13 years and subsequent depression at 17-19 years. In both studies only LL homozygous adolescents were at greater risk for depression with decreasing levels of positive parenting. Thus, while the S allele has previously been identified as a susceptible genotype, these findings suggest that the L allele may also confer sensitivity to depression in the face of specific environmental challenges.

PMID:
29094757
DOI:
10.1111/cdev.12987

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