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Pediatr Diabetes. 2018 May;19(3):346-353. doi: 10.1111/pedi.12597. Epub 2017 Nov 2.

Genetics of type 1 diabetes.

Author information

1
Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
2
Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado.
3
Diabetes Research Institute, Department of Medicine, Division of Endocrinology and Metabolism, Department of Microbiology and Immunology, Leonard Miller School of Medicine, University of Miami, Miami, Florida.

Abstract

Type 1 diabetes (T1D) results from immune-mediated loss of pancreatic beta cells leading to insulin deficiency. It is the most common form of diabetes in children, and its incidence is on the rise. This article reviews the current knowledge on the genetics of T1D. In particular, we discuss the influence of HLA and non-HLA genes on T1D risk and disease progression through the preclinical stages of the disease, and the development of genetic scores that can be applied to disease prediction. Racial/ethnic differences, challenges and future directions in the genetics of T1D are also discussed.

KEYWORDS:

HLA; epidemiology; etiology; genetics; type 1 diabetes

PMID:
29094512
PMCID:
PMC5918237
DOI:
10.1111/pedi.12597
[Indexed for MEDLINE]
Free PMC Article

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