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Nat Commun. 2017 Nov 1;8(1):1252. doi: 10.1038/s41467-017-01254-4.

Developmental increases in white matter network controllability support a growing diversity of brain dynamics.

Author information

1
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
2
Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
3
Department of Physics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
4
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. dsb@seas.upenn.edu.
5
Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, 19104, USA. dsb@seas.upenn.edu.

Abstract

As the human brain develops, it increasingly supports coordinated control of neural activity. The mechanism by which white matter evolves to support this coordination is not well understood. Here we use a network representation of diffusion imaging data from 882 youth ages 8-22 to show that white matter connectivity becomes increasingly optimized for a diverse range of predicted dynamics in development. Notably, stable controllers in subcortical areas are negatively related to cognitive performance. Investigating structural mechanisms supporting these changes, we simulate network evolution with a set of growth rules. We find that all brain networks are structured in a manner highly optimized for network control, with distinct control mechanisms predicted in child vs. older youth. We demonstrate that our results cannot be explained by changes in network modularity. This work reveals a possible mechanism of human brain development that preferentially optimizes dynamic network control over static network architecture.

PMID:
29093441
PMCID:
PMC5665937
DOI:
10.1038/s41467-017-01254-4
[Indexed for MEDLINE]
Free PMC Article

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