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Intern Med. 2018 Feb 15;57(4):587-590. doi: 10.2169/internalmedicine.9333-17. Epub 2017 Nov 1.

Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome Associated with Neuroendocrine Carcinoma of the Oropharynx.

Author information

1
Department of Neurology, Osaka University Graduate School of Medicine, Japan.
2
Department of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Japan.
3
Department of Pathology, Osaka University Graduate School of Medicine, Japan.
4
Department of Electrical and Electronics Engineering, Faculty of Engineering, Nagasaki Institute of Applied Science, Japan.

Abstract

Paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome (PCD-LEMS) are usually associated with small-cell lung carcinoma (SCLC). PCD-LEMS with extrapulmonary non-SCLC tumors; however, has not been previously reported. A 78-year-old man presented with dysarthria, dysphagia, staggering gait, and lower extremity muscle fatigue. He was diagnosed with PCD-LEMS associated with neuroendocrine carcinoma of the oropharynx, based on the histological findings of the biopsy, the existence of antibodies against P/Q-type voltage-gated calcium channels, and an incremental response of the compound muscle action potentials during repetitive nerve stimulation tests. Thus, PCD-LEMS should be included in the differential diagnosis of neurological dysfunction, even in extrapulmonary non-SCLC patients.

KEYWORDS:

Lambert-Eaton myasthenic syndrome (LEMS); antibodies against P/Q-type voltage-gated calcium channels (VGCC); neuroendocrine carcinoma; oropharyngeal cancer; paraneoplastic cerebellar degeneration (PCD)

PMID:
29093415
PMCID:
PMC5849558
DOI:
10.2169/internalmedicine.9333-17
[Indexed for MEDLINE]
Free PMC Article

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